Sequence files formats (FASTA and FASTQ) are commonly used in bioinformatics, molecular biology and biochemistry.With the advent of next-generation sequencing (NGS) technologies, the number of FASTQ datasets produced and analyzed has grown exponentially, urging the development of dedicated software to handle, parse, and manipulate such files effici
Abstract Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment.Recently, chimeric antigen receptor (CAR) T-cell therapy has been successfully applied in the treatment of B-cell malignancies, underscoring its great potential in antitumor therapy
Transfemoral amputation is a debilitating condition that leads to long-term mobility restriction and secondary disorders that negatively affect the quality of life of millions of individuals worldwide.Currently available prostheses are not able to restore energetically efficient and functional gait, thus, recently, the alternative strategy to injec
Abstract Geographic atrophy is an eye disease that greatly interferes with the daily lives of patients and their families, posing a serious threat to the aging European demographic.Over the past 30 months, timbren gmfk25s this initiative has assembled leading experts in the field of ophthalmology to share insights on the necessary policy steps that